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KMID : 1235520160150040095
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Research in Vestibular Science
2016 Volume.15 No. 4 p.95 ~ p.100
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Experiemental Model for Meniere’s Disease Using Surgical Ablation of Endolymphatic Sac
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Kim Min-Bum
Kim Mi-Joo
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Abstract
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Endolymphatic hydrops is a representing pathologic finding of Meniere's disease. For the induction of endolymphatic hydrops in an animal model, surgical ablation of endolymphatic sac has been used. Although traditional model with the blockage of endolymphatic sac induced severe hydrops, it has several limitations for the study of pathophysiology of Meniere's disease. Recently, modified experimental models have been introduced, in which additional procedure was performed to induce the acute aggravation of hydrops after the surgical ablation. These new models could be helpful to elucidate the mechanism and develop a new treatment of Meniere's disease. In this review, we introduce the characteristics of animal models using surgical ablation of endolymphatic sac from the classical model to novel modified models.
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KEYWORD
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Meniere disease, Endolymphatic hydrops, Animal model
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